Hi there,
I do not think you should go that granular on the URL structure unless you are planning to rank each child (folder) after the parent( main category). Also, Google will cut off some parts of the URL structure because it will be too long to show it in the SERPs. In addition, I would have a separate URL structure for products because I want to have the exact match product name in your URL and I want users to see it. Also, you should not forget about Google Analytics because with the long URL structure you will have a hard time going through metrics. That being said, I would make the URL structure in this way:
website.com/main-category
website.com/main-category/sub-category
website.com/main-category/sub-category/manufacture
Product URL
website.com/product/item-name ( manufacture name & product name )