I have seen a lot of sites that tie in main keywords closer together not rank as well as ones that use them in a more natural fashion.
We have done our own tests with this, and while it can take a while to find the right combination, the payoff is well worth it. When you construct the title, make sure the content, description and keyword list are all consistent.
On of the formats we have found to be successful for titles is to use the main keyword as the leader, and then be more descriptive in the secondary part of the title.
Example: Cane Beds | Boogie Beds Shopping Online Store
Keep in mind this is only an example, and could be polished better than this. If possible, use subpages to rank for additional terms or keywords rather than packing them all into one page and hoping for the best.
