Hi Ron,
I think there may be some value in building your YouTube presence for certain keywords, but you're looking at this situation all the wrong way round.
Really - you should start by looking at your business goals and determining whether, for a specific keyword, you want users to go to your site, or to YouTube to watch a video. If the keyword is informational and potentially appeals to individuals high up in your conversion funnel - that is to say, they aren't already engaged influencers or members of your community - then getting them to watch a video on YouTube that helps solve a specific problem or provides decent (non sales-focused) information might be the way to go.
If you're then able to create good content to fit with the user intent for that keyword - THEN you can think about optimising your YouTube videos and presence with specific keyword intent.
Don't start with the form (video) or the channel (youtube) but instead start with the audience and the business goals - then work out your strategy from there.
in terms of optimising for YouTube - basically, the Title should be treated like a title, the description like a meta description - then you need to drive targeted engagement (not just raw views) in order to get the video ranking. Embeds and links also help, and uploading a transcription manually will allow you to rank for longer tail phrases which match the text in the transcription itself.
I hope that's useful.