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Hey there! Tawny from Moz's Help Team here. Unfortunately, there's no way to change the URL a campaign is tracking once the campaign is started. If you need to track a new domain, you'll need to archive or delete a campaign to make room for the new one. I hope that helps! If you still have questions, feel free to write in to us at help@moz.com and we'll do our best to help with any and all issues you might run into.

Can you be more specific on the limitations you are inquiring about? The questions leaves room for a lot of varied answers. For example, are you referring to the specific advertising policies for a country? That would be whether or not a certain piece of content / product is able to be advertised through AdWords. Or Are you more looking for features that you would want to have in placed to improve SEO/SEM in particular countries? Example: having proper NAP (name, address, phone #) in place for each location being targeted, which would improve SEO/SEM in those countries. If looking at specific advertising policies then I suggest going straight to Google. Example policy: https://support.google.com/adwordspolicy/answer/176031?hl=en This article speaks to the healthcare advertising policies for countries. If looking for specific location strategies, then I suggest looking through Moz's Local Learning center to understand the nuances of local marekting. That can be found here: http://moz.com/learn/local