Hey Dana,
I've had this problem with Safari being slower as well. In fact, I just checked a handful of sites in Google Analytics and Safari is almost consistently the slowest browser. One question to look into is whether or not mobile traffic on Safari is slow. For the sites I'm looking at and for the sites I've worked on in the past, the culprit is usually Safari's desktop browser. Phones are usually within normal loading parameters (by phone standards).
Unfortunately, in most cases, the sluggish performance on Safari is due to Safari's DNS prefetching. Generally, prefetching does the opposite, but apparently can slow you down in Safari. You can read more about that here. http://macs.about.com/od/MacTroubleshootingTips/qt/Troubleshooting-Safari-Slow-Page-Loads-Caused-By-Dns-Prefetching.htm and this is another good one http://computers.tutsplus.com/tutorials/how-to-fix-slow-and-non-loading-webpages-in-safari--mac-51338 (Lots more if you Google Safari prefetching.)
I do think it is worth it to try to fix it. Here's what I would do, if I were you. Feel free to PM me if you want more help...
The way you fix this is on the client's machine, at least according to those articles (and others I've found while Google'ing around just now). However, you can try these steps out on your computer (if you've got a Mac) and see if you have an improved performance in Safari. It shouldn't take that long to test, and is probably worth it given the huge loss you are seeing due to this issue.
The next question is, well, how do I do this for everybody? The answer is to ask your visitors to use Chrome!
No, seriously, one that worked for me in the past, was to detect the Safari user agent and load a slightly different version of the page that required fewer requests, meaning there will be less for Safari to prefetch. For instance, you might get rid of JavaScript, images, etc. that isn't essential. Obviously, keep the core content so that the pages are basically the same (kind of like you would for mobile detection).
This is obviously much more complicated to setup as it requires adjustments to the design as well as the code structure. But, generally simpler than trying to redo your entire website.
Before you make any such changes, it might be worth running a simple test on a key landing page that gets a lot of visits from Safari. Remove what elements you can for all user agents and see if this changes anything substantially with the site speed in Safari.
I hope that helps. Thanks,
Matthew