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Thanks and yes that's what i have now done with the microsites. So thank you very much for your advice. The subdomains rank too well for me to bite the bullet on these too, or at least for the moment. A slightly different and better suited analogy would be "my main site advertises Hotels and each sub-domain advertises Hotels in London, etc, although my main site also advertises the same Hotels" FYI my site has an Adult Theme (although not porn) which is why i am not posting URL's. Thanks again!! Jon

Probably, you can set pointing to the lower case URL. So, even though the upper case and lower case are actually no difference for us, search engines may assume the lower case url will be the primary one. Other alternative maybe to have a regular expression to redirect/rewrite the capitals into lower case.

Ok i will see what can be done about the duplicate content. Will adding META NOINDEX, NOFOLLOW to the empty directory pages i have, cure any problems that Google may have? (will NOINDEX also stop these pages from showing as duplicate content in SEOmoz, or will they still be shown?) I have also spotted that several of the duplicate pages are due to www and non-www So i have updates the settings in Google WebMaster Tools to only list www and also added a .htaccess 301 redirect so all users are directed to www.  Is this the best thing to do? Thanks Jon

No problem, first time setting up can be tricky. Good luck.