ONLY in the terms of speed. If you are targeting New Yorkers, you probably want to serve them as fast as possible. An offshore server will deliver slower that a server in Virginia (Amazon AWS) for example.
Using a CDN can probably eliminate that issue as almost ALL CDN providers have multiple servers across the US, still the dynamic content will be loaded from the main server, but that is usually the smallest amount of data (while CSS and JS files are usually what slows down loading and rendering).
Hope that helps!

