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Personally I will begin by following any accounts I feel may be influential or interested in the field I am marketing. Out of 'Twitter courtesy' you will see roughly 20-40% of these follw you back. If there are any particular accounts I want to follow me I will mention one of their previous tweets before following them. That tends to work to an extent. Once I have a following, with the companies actual Tweets I tend to Tweet articles, videos, pictures etc that are relevant to their interests e.g. An article on 'Podiatry vs Chiropody' with each of the terms hashtagged.I'll only hashtag certain words I think are relevant to the tweet. Rather than RT other tweets I mentioned the person and put the Tweet via @whoeveritmaybe. Also I find it important to add some sort of opinion to the informational tweets. It gives the account an element of humanization rather than just looking like a bot pushing out articles. Also important to respond to any mentions no matter how negative/random they may seem at the time. This is quite an over simplisation (and there are a lot more things I do) of what occurs but I think you get the jist of what I'm getting at P.S - I wouldn't use hundreds of hashtags - I think even though you'll appear in more #searches# it will reduce the chance of followers engaging and any click throughs on content you're pushing

Tossing this idea out for discussion.... One way that google detects manipulation is the presence of links that point to entirely unrelated websites - especially if they have optimized anchor text.  A link like that could paint a small target on either site. Is it worth the small risk?