Cant find good information on webmaster tools geographic target and have some questions about it.

[EcommerceSite]

Going through our webmaster tools setting I noticed someone had checked Target Users and selected United States. Most of our business is in the US but we still do some internationally. If I uncheck it will I lose rankings in the US?

[Andropenis_Australia]

I would say most likely yes. US sites still show internationally so if your main target audience is in the U.S I would keep that as the target rather than risk anything. All the best.