I am optimizing title tags and was wondering if it makes a difference if I use "commas" in between keywords that are synonyms or should I use "and" instead?

[EcomLkwd]

For example: "pants, trousers at pants.com" or "pants and trousers at pants.com".

[EvolveCreative]

In terms of rankings - no can give you that answer but Google.

In my opinion, I'd go with 'and' though. It looks more legitimate in the search results - thus hopefully increasing CTR.

[EcomLkwd]

Thanks David!

[irvingw]

matt cutts addresses

http://www.youtube.com/watch?v=jHSqLYUPq8w#t=0m22s

I found this brief discussion on semoz

http://www.seomoz.org/q/using-commas-in-the-tittle-tag